Peng-Fei Han,Xian-Da Che,Hong-Zhuo Li,Yang-Yang Gao,Xiao-Chun Wei,Peng-Cui Li.[J].Chin J Traumatol,2020,23(2):96-101. [doi]
Annexin A1 involved in the regulation of inflammation and cell signaling pathways
  
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KeyWord: Annexin A1InflammatorySignal pathwayCell proliferationApoptosis
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Author NameAffiliation
Peng-Fei Han Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China 
Xian-Da Che Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China 
Hong-Zhuo Li Department of Orthopaedic Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China 
Yang-Yang Gao Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China 
Xiao-Chun Wei Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China 
Peng-Cui Li Department of Orthopaedic Surgery, the Second Hospital of Shanxi Medical University, Taiyuan 030009, China 
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Abstract:
      With the deepening of research, proteomics has developed into a science covering the study of all the structural and functional characteristics of proteins and the dynamic change rules. The essence of various biological activities is revealed from the perspectives of the biological structure, functional activity and corresponding regulatory mechanism of proteins by proteomics. Among them, phospholipid-binding protein is one of the hotspots of proteomics, especially annexin A1, which is widely present in various tissues and cells of the body. It has the capability of binding to phospholipid membranes reversibly in a calcium ion dependent manner. In order to provide possible research ideas for researchers, who are interested in this protein, the biological effects of annexin A1, such as inflammatory regulation, cell signal transduction, cell proliferation, differentiation and apoptosis are described in this paper.
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