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| Zi-Sen Zhang,He-Nan Zhou,Shuang-Shuang He,Ming-Ying Xue,Tao Li,Liang-Ming Liu.[J].Chin J Traumatol,2020,23(2):89-95. [doi] |
| Research advances in pericyte function and their roles in diseases |
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| DOI： |
| KeyWord: PericytesVascular diseasesMicrocirculation |
| FundProject: |
| Author Name | Affiliation | | Zi-Sen Zhang | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400042, China | | He-Nan Zhou | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400043, China | | Shuang-Shuang He | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400044, China | | Ming-Ying Xue | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400045, China | | Tao Li | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400046, China | | Liang-Ming Liu | State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing 400047, China |
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| Abstract: |
| Pericyte, a kind of pluripotent cell, may regulate the irrigation flow and permeability of microcirculation. Pericytes are similar to the smooth muscle cells, which express several kinds of contractile proteins and have contractility. The dysfunction of pericytes is related to many microvascular diseases, including hypoxia, hypertension, diabetic retinopathy, fibrosis, inflammation, Alzheimer's disease, multiple sclerosis, and tumor formation. For a long time, their existence and function have been neglected. The distribution, structure, biomarker, related signaling pathways as well as the roles of pericytes on vascular diseases will be introduced in this review. |
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