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| Maryam Malek,Jalal Hassanshahi,Reza Fartootzadeh,Fatemeh Azizi,Somayeh Shahidani.[J].Chin J Traumatol,2018,21(1):4-10. [doi] |
| Nephrogenic acute respiratory distress syndrome: A narrative review on pathophysiology and treatmenton pathophysiology and treatment |
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| DOI： |
| KeyWord: Acute kidney injury
Acute lung injury
Renal failure
Respiratory distress syndrome
Multiple organ failure |
| FundProject: |
| Author Name | Affiliation | | Maryam Malek | Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | | Jalal Hassanshahi | Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | | Reza Fartootzadeh | Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | | Fatemeh Azizi | Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran | | Somayeh Shahidani | Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran |
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| Abstract: |
| The kidneys have a close functional relationship with other organs especially the lungs. This connection makes the kidney and the lungs as the most organs involved in the multi-organ failure syndrome. The combination of acute lung injury (ALI) and renal failure results a great clinical significance of 80% mortality rate. Acute kidney injury (AKI) leads to an increase in circulating cytokines, chemokines, activated innate immune cells and diffuse of these agents to other organs such as the lungs. These factors initiate pathological cascade that ultimately leads to ALI and acute respiratory distress syndrome (ARDS). We comprehensively searched the English medical literature focusing on AKI, ALI, organs cross talk, renal failure, multi organ failure and ARDS using the databases of PubMed, Embase, Scopus and directory of open access journals. In this narrative review, we summarized the pathophysiology and treatment of respiratory distress syndrome following AKI. This review promotes knowledge of the link between kidney and lung with mechanisms, diagnostic biomarkers, and treatment involved ARDS induced by AKI. |
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