Marc Maegele,Zheng-Tao Gu,Qiao-Bing Huang,Hong Yang.[J].Chin J Traumatol,2017,20(3):125-132. [doi]
Updated concepts on the pathophysiology and the clinical management of trauma hemorrhage and coagulopathy
  
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KeyWord: HemorrhageBlood coagulation disordersHemostaticsBlood transfusion
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Author NameAffiliation
Marc Maegele Department for Trauma and Orthopedic Surgery, Cologne-Merheim Medical Center (CMMC), University Witten/Herdecke (UW/H), Campus Cologne-Merheim, Ostmerheimerstr 200, D-51109 Koln, Germany
Institute for Research in Operative Medicine (IFOM), University Witten/Herdecke (UW/H), Campus Cologne-Merheim, Ostmerheimerstr 200, D-51109 Koln, Germany 
Zheng-Tao Gu Department of Intensive Care, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China
Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University, Guangzhou 510515,PR China 
Qiao-Bing Huang Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University, Guangzhou 510515, 
Hong Yang Department of Intensive Care, The Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, PR China
Department of Pathophysiology, Guangdong Provincial Key Laboratory of Shock and Microcirculation Research, Southern Medical University, Guangzhou 510515,PR China 
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Abstract:
      Uncontrolled hemorrhage and subsequent trauma-induced coagulopathy (TIC) are still the principle causes for preventable death after trauma and early detection and aggressive management have been associated with reduced mortality. Despite increasing knowledge about trauma resuscitation, best practice to treat this newly defined entity is still under debate. A synopsis of best current knowledge with reference to the updated European trauma guideline on the management of severe trauma hemorrhage and TIC is presented. The implementation of evidence-based local protocols and algorithms including clinical quality and safety management systems together with parameters to assess key measures of bleeding control and outcome is advocated.
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