Dong Wang,Yang Liu,Yan-Rui Zhao,Jun-Lin Zhou.[J].Chin J Traumatol,2016,19(4):193-198. [doi]
Low dose of lipopolysaccharide pretreatment can alleviate the inflammatory response in wound infection mouse model
  
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KeyWord: LipopolysaccharidesInflammatory reactionSurgical wound infection
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Author NameAffiliation
Dong Wang Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China 
Yang Liu Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China 
Yan-Rui Zhao Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China 
Jun-Lin Zhou Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China 
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Abstract:
      Purpose: To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods: Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial longitudinal incision was made and infected with different bacteria. Results: It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coli compared with doses of 0.25 mg/kg/time, 1 mg/kg/time, and 1.5 mg/kg/time. Conclusions: LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs' function.
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