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| Jian-Min Wang,Jing Chen.[J].Chin J Traumatol,2016,19(3):125-128. [doi] |
| Damage of vascular endothelial barrier induced by explosive blast and its clinicalsignificance |
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| DOI： |
| KeyWord: Blast injuries
Vascular endothelial cells
Blood brain barrier
Bloodeair barrier |
| FundProject: |
| Author Name | Affiliation | | Jian-Min Wang | State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery/Daping Hospital, Third Military Medical University, Chongqing 400042, China | | Jing Chen | State Key Laboratory of Trauma, Burn and Combined Injury, Research Institute of Surgery/Daping Hospital, Third Military Medical University, Chongqing 400042, China |
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| Abstract: |
| In recent years, injuries induced by explosive blast have got more and more attention owing to weapon
development and frequent terrorist activities. Tear, bleeding and edema of tissues and organs are the
main manifestations of blast shock wave damage. Vascular endothelial barrier is the main defense of
tissues and organs' integrity. This article aims to discuss possible mechanisms of endothelial barrier damage induced by explosive blast and main manifestations of blood brain barrier, bloodeair barrier, and intestinal vascular barrier impairments. In addition, the main regulatory factors of vascular permeability are also summarized so as to provide theoretical basis for prevention and cure of vascular endothelial barrier damage resulting from explosive blast. |
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