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| Mohammad Reza Farahpour,Aydin Dilmaghanian,Maisam Faridy,Esmaeil Karashi.[J].Chin J Traumatol,2016,19(2):97-103. [doi] |
| Topical Moltkia coerulea hydroethanolic extract accelerates the repairof excision wound in a rat model |
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| DOI： |
| KeyWord: Moltkia coeruleaExcision wound healingCollagen synthesisAnti-oxidantRats |
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| Author Name | Affiliation | | Mohammad Reza Farahpour | Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran | | Aydin Dilmaghanian | Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran 14155-6453, Iran | | Maisam Faridy | Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran | | Esmaeil Karashi | Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran |
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| Abstract: |
| Purpose: To evaluate the effect of a hydroethanolic extract of Moltkia coerulea ointment (MCO) on the
healing of excision wound in a rat model.
Methods: Circular surgical full thickness excision wound, with 314 mm2 size, was induced in the
anterior-dorsal side of each rat. Three different doses of MCO (1%, 3% and 6%) were administrated. On Day 3, 7, 14 and 21, the tissue was sampled and immune cells, fibroblasts and fibrocytes distribution per one mm2 of wound area, collagen density and re-epithelialization were analyzed. Moreover, the total flavnoid, phenols and anti-oxidant potential of the MCO were evaluated. Ultimately, the percentage of wound contraction in different groups was compared with each other.
Results: Hydroethanolic extract of MCO significantly (p<0.05) increased wound contraction percentage. The animals in medium and high dose MCO-treated groups exhibited remarkably (p<0.05) higher fibroblast and fibrocyte distribution and significantly (p<0.05) lower immune cells infiltration. On Day 7 after injury, MCO up-regulated neovascularization in a dose-dependent way.
Conclusion: Our data showed that MCO shortened the inflammation phase by provoking the fibroblast
proliferation. Moreover, MCO promoted the healing process by up-regulating the angiogenesis and
provoking the structural cells proliferation as well as increasing the collagen synthesis, cross-linking, and deposition. |
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