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| Baiqiang Li,Haichen Sun.[J].Chin J Traumatol,2015,18(2):95-97. [doi] |
| Research progress of acute coagulopathy of trauma-shock |
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| DOI： |
| KeyWord: Acute coagulopathy of trauma-shock ACoTS Trauma Shock |
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| Abstract: |
| Acute coagulopathy of trauma-shock (ACoTS) occurs in
25% of patients with severe trauma in the early phase, and
the mortality of those patients is four-fold higher than
patients without coagulopathy. The pathophysiology of this
complicated phenomenon has been focused on in recent
years. Tissue injury and hypoperfusion, activated protein C
and Complements play important roles in the early phase
after trauma. While the use of blood products, hypothermia,
acidosis and inflammation are the main mechanism in late
phase. Supplementing coagulation factors and platelets to
improve ACoTS are inefficient. Only positive resuscitation
from shock and improving tissue hypoperfusion have
expected benefits. |
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