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| Kefei Chen,Jirong Dong,Tian Xia,Chunlei Zhang,Wei Zhao,Qinyi Xu,Xuejian Cai.[J].Chin J Traumatol,2015,18(2):90-94. [doi] |
| Changes in cerebral hemodynamics in patients with posttraumatic diffuse brain swelling after external intraventricular drainage |
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| DOI： |
| KeyWord: Brain injuries Brain edema Perfusion imaging Hemodynamics |
| FundProject: |
| Author Name | Affiliation | | Kefei Chen | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA | | Jirong Dong | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA | | Tian Xia | Department of Neurosurgery, Clinical Medicine School of Jiangsu University | | Chunlei Zhang | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA | | Wei Zhao | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA | | Qinyi Xu | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA | | Xuejian Cai | Department of Neurosurgery, Craniocerebral Trauma Cure Center of PLA, 101st Hospital of PLA |
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| Abstract: |
| Purpose: To investigate the changes of cerebral hemodynamics pre- and post-ventricular drainage in
patients with posttraumatic acute diffuse brain swelling.
Methods: Twenty-four cases of traumatic diffuse brain swelling were analyzed retrospectively. Patients in nonsurgical group were treated by medicine therapy. Patients in surgical group were treated by external ventricular drainage plus medicine therapy. The first CT perfusion scan was completed within 4-5 h after trauma and scanned again after 7 days. The changes of perfusion parameters in area-ofinterest in two groups were analyzed and compared before and after treatment.
Results: Compared with the nonsurgical group, the value of cerebral blood volume, cerebral blood flow and mean transit time in bilateral frontal temporoparietal grey matter, basal ganglia, cerebellum, and brain stem at pre- and post-therapy were increased significantly (p < 0.05) in surgical group, and consequently the prognosis of patients undergoing surgery was also better than that of nonsurgical group.
Conclusion: External ventricular drainage can improve cerebral perfusion and increase survival quality for the patients with posttraumatic acute diffuse brain swelling. |
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