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| Ziqiang Zhou,Dongping Ye,Weiguo Liang,Bin Wang,Zhenzhong Zhu.[J].Chin J Traumatol,2015,18(1):33-38. [doi] |
| Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen |
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| DOI： |
| KeyWord: Calcium phosphate cement Injectability Compressive strength |
| FundProject: |
| Author Name | Affiliation | | Ziqiang Zhou | Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University | | Dongping Ye | Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University | | Weiguo Liang | Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University | | Bin Wang | Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University | | Zhenzhong Zhu | Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University |
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| Abstract: |
| Purpose: To develop a novel injectable strontium-containing calcium phosphate cement with collagen.
Methods: A novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element, collagenⅠ, and modified starch; the injectability, solidification time, microstructure, phase composition, compressive strength, anti-collapsibility and histological properties of material were evaluated.
Results: The results showed that the material could be injected with an excellent performance; the modified starch significantly improved the anti-washout property of cement; with the liquid to solid ratio of 0.3, the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa); histological examination of repair tissue showed that the bone was repaired after 16 weeks; the degradation of
cement was consistent with the new bone growth.
Conclusion: A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared, with addition of modified starch. The CPC showed a good antiwashout property and the degradation time of the cement met with the new bone growing. This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects. |
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